Amino acid disorder
نویسندگان
چکیده
منابع مشابه
Predicting intrinsic disorder from amino acid sequence.
Blind predictions of intrinsic order and disorder were made on 42 proteins subsequently revealed to contain 9,044 ordered residues, 284 disordered residues in 26 segments of length 30 residues or less, and 281 disordered residues in 2 disordered segments of length greater than 30 residues. The accuracies of the six predictors used in this experiment ranged from 77% to 91% for the ordered region...
متن کاملPerformance of protein disorder prediction programs on amino acid substitutions.
Many proteins contain intrinsically disordered regions, which may be crucial for function, but on the other hand be related to the pathogenicity of variants. Prediction programs have been developed to detect disordered regions from sequences and used to predict the consequences of variants, although their performance for this task has not been assessed. We tested the performance of protein diso...
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Previous results indicated that performance of chicks fed a high level (10%) of poultry by-product meal(PBM) was lower than performance of chicks fed a corn-soybean meal (SBM) diet. The latter difference was hypothesized to be due to variation in digestible amino acid (AA) levels among the diets. This study evaluated diets containing PBM formulated on equivalent total AA basis vs. an equivalent...
متن کاملMinimizing amino acid catabolism decreases amino acid requirements.
The processes of natural selection shape the efficiency of nutrient use by animals, with some being especially thrifty while others are wasteful. An examination of the widely divergent amino acid economies of different species vividly illustrates this basic nutritional principle. The domestic cat evolved as a carnivore and has a very high maintenance requirement for dietary amino acids. The cat...
متن کاملRole of amino acid transporters in amino acid sensing.
Amino acid (AA) transporters may act as sensors, as well as carriers, of tissue nutrient supplies. This review considers recent advances in our understanding of the AA-sensing functions of AA transporters in both epithelial and nonepithelial cells. These transporters mediate AA exchanges between extracellular and intracellular fluid compartments, delivering substrates to intracellular AA sensor...
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ژورنال
عنوان ژورنال: Nature
سال: 1975
ISSN: 0028-0836,1476-4687
DOI: 10.1038/255354b0